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Journal of Antimicrobial Chemotherapy (2002) 50, 23-27
© 2002 The British Society for Antimicrobial Chemotherapy

Supplement

Clinical efficacy of cefpodoxime in respiratory tract infection

Robert Cohen*

Department of Microbiology, Intercommunal Hospital of Créteil, Créteil, France

Abstract

Acute otitis media (AOM), sinusitis and tonsillopharyngitis are respiratory tract infections frequently encountered by primary-care physicians. Increasing bacterial resistance, particularly in Streptococcus pneumoniae, which is one of the most important respiratory tract bacteria implicated in community-acquired respiratory tract infections, has led to concern about the current options for empirical antibiotic treatment and has prompted a search for effective alternative treatments. Data from in vitro studies show that cefpodoxime has good activity against the main respiratory tract pathogens, S. pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pyogenes. Clinical studies confirm the efficacy of cefpodoxime in AOM, sinusitis and tonsillopharyngitis. As with all broad-spectrum antibiotics, there is the risk of promotion of bacterial resistance associated with overuse. However, if used with care, cefpodoxime can be considered as an alternative for empirical treatment of bacterial respiratory tract infections encountered in general practice, particularly where penicillins and macrolides have reduced efficacy against the main bacterial pathogens.

Footnotes

* Correspondence address. Centre Hospitalier de Créteil, 94010 Créteil Cedex, France. E-mail: robert.cohen{at}wanadoo.fr


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