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JAC Advance Access originally published online on November 18, 2002
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Journal of Antimicrobial Chemotherapy (2002) 50, 903-906
© 2002 The British Society for Antimicrobial Chemotherapy

Comparison of the antibacterial activities of ampicillin, ciprofloxacin, clarithromycin, telithromycin and quinupristin/dalfopristin against intracellular non-typeable Haemophilus influenzae

Irini Lazou Ahrén, Eva Karlsson, Arne Forsgren and Kristian Riesbeck*

Department of Medical Microbiology, University Hospital Malmö, Lund University, S-205 02 Malmö, Sweden

Received 25 March 2002; returned 28 May 2002; revised 16 August 2002; accepted 27 August 2002

Non-typeable Haemophilus influenzae, which is a cause of disease in the upper and lower respiratory tract, can survive intracellularly in human epithelial cells and macrophages. We studied the in vitro activity of five antibiotics against intracellular non-typeable H. influenzae in human type II alveolar epithelial cells. The eukaryotic cells were loaded with bacteria, and extracellular bacteria were killed by gentamicin. After the cells were washed, antibiotics were added at concentrations of 0.12–64 mg/L for 18 h before the numbers of viable intracellular bacteria were determined. Of the antibiotics tested, ciprofloxacin and quinupristin/dalfopristin were the most potent agents, followed by clarithromycin and telithromycin. Ampicillin was not active against intracellularly localized, non-typeable H. influenzae.

* Corresponding author. Tel: +46-40-331340; Fax: +46-40-336234; E-mail: kristian.riesbeck{at}mikrobiol.mas.lu.se


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