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JAC Advance Access originally published online on November 1, 2002
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Journal of Antimicrobial Chemotherapy (2002) 50, 873-876
© 2002 The British Society for Antimicrobial Chemotherapy

A fusidic acid-resistant clone of Staphylococcus aureus associated with impetigo bullosa is spreading in Norway

Yngvar Tveten1,*, Andrew Jenkins1 and Bjørn-Erik Kristiansen1,2

1 Telemark Biomedical Centre, A/S Telelab, Department of Medical Microbiology, Strømdaljordet 4, PO Box 1868, N-3703 Skien; 2 Department of Microbiology and Virology, University of Tromsø, N-9037 Tromsø, Norway

Received 2 July 2002; returned 9 August 2002; revised 20 August 2002; accepted 20 August 2002

Objective: To investigate the possibility that the increased prevalence of fusidic acid-resistant Staphylococcus aureus in Norway is caused by clonal spread.

Methods: Fusidic acid-resistant and -susceptible clinical isolates of S. aureus from patients with skin infections in the Norwegian county of Telemark and fusidic acid-resistant isolates from other parts of Scandinavia were compared. MICs of fusidic acid for bacterial isolates and pulsed-field gel electrophoresis (PFGE) patterns were investigated. Prevalence data for fusidic acid-resistant S. aureus for the period 1992–2001 were obtained.

Results: The prevalence of fusidic acid resistance in S. aureus increased from 1992 to 2001. Eighty per cent of the resistant isolates investigated shared an identical PFGE pattern. The same pattern was found in fusidic acid-resistant isolates from other parts of Scandinavia. Fusidic acid-resistant S. aureus was typically found in impetigo bullosa-like skin disease in children mostly in the summer months.

Conclusions: Fusidic acid resistance among S. aureus is increasing in Norway and is predominantly caused by one clone of S. aureus. The clone may spread further to other countries, and dissemination may be facilitated by extensive use of topical fusidic acid.

Keywords: pulsed-field gel electrophoresis, MIC, clonal

* Corresponding author. Tel: +47-3550-5707; Fax: +47-3550-5701; E-mail: yngvar.tveten{at}telelab.no


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