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JAC Advance Access originally published online on November 1, 2002
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Journal of Antimicrobial Chemotherapy (2002) 50, 1039-1043
© 2002 The British Society for Antimicrobial Chemotherapy

Mechanisms of ß-lactam resistance in Pseudomonas aeruginosa: prevalence of OprM-overproducing strains in a French multicentre study (1997)

J. D. Cavallo1,*, P. Plesiat2, G. Couetdic2, F. Leblanc3, R. Fabre and Groupe d’Etude de la Résistance de Pseudomonas aeruginosa aux Bêtalactamines (GERPB)1,§

1 Hôpital d’Instruction des Armées Bégin, 69 Avenue de Paris, 94163 St Mandé; 2 Faculté de Médecine de Besançon, Besançon; 3 Laboratoire Glaxo-Wellcome, 100 route de Versailles, 78163 Marly le Roi, France

Received 3 April 2002; returned 13 June 2002; revised 12 July 2002; accepted 23 July 2002

One hundred and forty-three non-repetitive strains of Pseudomonas aeruginosa were collected in 13 French hospitals in 1997. A decreased susceptibility or resistance to ticarcillin (MIC > 16 mg/L) was found in 61 isolates (43%) and this was attributed to three major mechanisms: (i) overexpression of OprM and hence related efflux components such as MexAB or MexXY (42.6%), (ii) production of acquired ß-lactamase (29.5%) and (iii) overexpression of chromosomally encoded AmpC cephalosporinase (21.3%). Four of seven ‘intrinsically’ resistant strains (11.5%) with normal amounts of OprM were shown to produce low levels of AmpC, whereas in three isolates no resistance mechanism to ß-lactams could be identified. Overproduction of OprM thus appears as an important mechanism of ticarcillin resistance in French isolates of P. aeruginosa.

* Corresponding author. Tel: +33-1-43984734; Fax: +33-1-43985336; E-mail: hia-begin-biologie{at}worldonline.fr

§ The GERPB participants are listed in the Acknowledgements.


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