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JAC Advance Access originally published online on November 18, 2002
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Journal of Antimicrobial Chemotherapy (2002) 50, 1027-1030
© 2002 The British Society for Antimicrobial Chemotherapy

Amphotericin B lipid complex exerts additive antifungal activity in combination with polymorphonuclear leucocytes against Scedosporium prolificans and Scedosporium apiospermum

Cristina Gil-Lamaignere1, Emmanuel Roilides1, Avgi Maloukou1, Irene Georgopoulou2, George Petrikkos2 and Thomas J. Walsh3,*

1 Third Paediatric Department, Aristotle University, Hippokration Hospital, Thessaloniki GR-54642; 2 First Propedeutic Department of Medicine, Athens University, Athens GR-11527, Greece; 3 Immunocompromised Host Section, Paediatric Oncology Branch, National Cancer Institute, Building 10, Room 13N240, Bethesda, MD 20892, USA

Received 29 July 2002; accepted 9 August 2002

Scedosporium prolificans and Scedosporium apiospermum are resistant to most antifungal agents and cause refractory pulmonary and disseminated infections. The combined effects of deoxycholate amphotericin B, amphotericin B lipid complex and liposomal amphotericin B with human polymorphonuclear leucocytes (PMNs) in damaging hyphae of these fungi were evaluated by XTT assay. Amphotericin B lipid complex displayed a significant additive effect with PMNs against both Scedosporium species (22% for S. prolificans and 81% for S. apiospermum; P < 0.04). None of the formulations adversely affected the PMN antifungal activity. These findings may be important in designing better strategies for management of infections due to these organisms.

Keywords: amphotericin B formulations, Scedosporium, polymorphonuclear leucocytes

* Corresponding author. Tel: +1-301-402-0023; Fax: +1-301-402-0575; E-mail: walsht{at}mail.nih.gov


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