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JAC Advance Access originally published online on November 18, 2002
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Journal of Antimicrobial Chemotherapy (2002) 50, 1011-1015
© 2002 The British Society for Antimicrobial Chemotherapy

Rifampicin concentrations in bronchial mucosa, epithelial lining fluid, alveolar macrophages and serum following a single 600 mg oral dose in patients undergoing fibre-optic bronchoscopy

Hisham M. Ziglam1, David R. Baldwin1, Ian Daniels1, Jenny M. Andrews2 and Roger G. Finch1,*

1 Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB; 2 Antibiotic Research Laboratory, City Hospital NHS Trust, Dudley Road, Birmingham B18 7QH, UK

Received 8 April 2002; returned 24 June 2002; revised 2 August 2002; accepted 15 August 2002

The concentrations of rifampicin in epithelial lining fluid (ELF), human alveolar macrophages (AM), bronchial mucosal biopsies and serum were measured after a single oral dose of 600 mg rifampicin from 15 patients undergoing fibre-optic bronchoscopy. The samples of ELF, AM, the bronchial mucosal biopsies and serum were obtained ~2–5 h after dosing. The mean concentrations (mean ± standard error) were 5.25 mg/L (±0.67) in ELF, 7.93 mg/kg (±1.61) in bronchial biopsies, 15.48 mg/L (±1.41) in serum and 251.8 mg/L (±65.92) in alveolar macrophages. These site concentrations exceeded the MIC90 for common respiratory pathogens including Mycobacterium tuberculosis and support the observed clinical efficacy of rifampicin in the treatment of a wide range of respiratory tract infections.

* Corresponding author. Tel: +44-115-840-4741; Fax: +44-115-840-4742; E-mail: roger.finch{at}nottingham.ac.uk


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