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JAC Advance Access originally published online on September 20, 2002
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Journal of Antimicrobial Chemotherapy (2002) 50, 751-754
© 2002 The British Society for Antimicrobial Chemotherapy

Evidence for the efficacy of artesunate in asymptomatic Plasmodium malariae infections

Steffen Borrmann1,2,*, Nicole Szlezák1,3, Ronald K. Binder1, Michel A. Missinou1,2, Bertrand Lell1,2 and Peter G. Kremsner1,2

1 Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, B. P. 118, Gabon; 2 Department of Parasitology, Institute of Tropical Medicine, University of Tübingen, Wilhelmstrasse 27, D-72074 Tübingen, Germany; 3 John F. Kennedy School of Government, Harvard University, Cambridge, MA 02138, USA

Received 10 January 2002; returned 16 May 2002; revised 29 May 2002; accepted 12 August 2002

This study evaluated the efficacy and safety of a 3-day course of artesunate (4 mg/kg/day) for asymptomatic Plasmodium malariae infections. The parasitological cure rates on days 7 and 56 in the group treated with artesunate were 100% and 83%, respectively, compared with no cure in the placebo group (P < 0.0001).

Keywords: Plasmodium malariae, artesunate, chemotherapy, malaria, Gabon

* Corresponding author. Tel: +49-7071-29-80234; Fax: +49-7071-29-4684; E-mail: steffen.borrmann{at}uni-tuebingen.de


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