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JAC Advance Access originally published online on October 22, 2002
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Journal of Antimicrobial Chemotherapy (2002) 50, 747-750
© 2002 The British Society for Antimicrobial Chemotherapy

Linezolid penetration into osteo-articular tissues

B. Rana1,*, I. Butcher2, P. Grigoris1, C. Murnaghan1, R. A. Seaton3 and C. M. Tobin4

1 University Department of Orthopaedics, 2 Department of Microbiology and 3 Department of Infectious Diseases, Western Infirmary and Gartnavel General Hospital, Dumbarton Road, Glasgow G11 6NT, UK; 4 Bristol Centre for Antimicrobial Research and Evaluation, Department of Microbiology, Southmead Hospital, Bristol BS10 5NB, UK

Received 8 November 2001; returned 26 June 2002; revised 29 July 2002; accepted 19 August 2002

Penetration of linezolid into osteo-articular tissue and fluid was studied in 10 patients undergoing primary total knee replacement. Linezolid 600 mg 12 hourly was given orally over the 48 h before operation and intravenously 1 h before induction of anaesthesia. Mean concentrations of linezolid at 90 min after the final dose, in serum, synovial fluid, synovium, muscle and cancellous bone, assayed by HPLC, were at least twice the MIC90 for staphylococci and streptococci. The concentrations obtained indicate good penetration of this antibiotic and support its use in the management of multidrug-resistant Gram-positive bone, joint and deep-seated soft-tissue infections.

Keywords: linezolid, oxazolidinone, bone and joint infection, osteomyelitis, osteo-articular tissue, pharmacokinetics

* Corresponding author. Tel: +44-141-211-2000; Fax: +44-141-339-0462


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