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JAC Advance Access originally published online on September 6, 2002
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Journal of Antimicrobial Chemotherapy (2002) 50, 607-609
© 2002 The British Society for Antimicrobial Chemotherapy

Brain tissue penetration of ciprofloxacin following a single intravenous dose

Marc Leone1,*, Emmanuelle Sampol-Manos2, Dominique Santelli1, Stéphanie Grabowski2, Bernard Alliez3, Alain Durand2, Bruno Lacarelle2 and Claude Martin1

1 Intensive Care Unit and Trauma Center and 3 Department of Neurosurgery, Nord Hospital, Marseilles School of Medicine, Marseilles; 2 Department of Pharmacokinetics, Timone Hospital, France

Received 18 February 2002; returned 8 May 2002; revised 18 June 2002; accepted 15 July 2002

Ciprofloxacin distribution was assessed in cerebral tissues in 14 patients undergoing craniotomy. The study objective was to determine the brain tissue/serum concentration ratio of ciprofloxacin. Patients received a single intravenous (iv) 200 mg dose of ciprofloxacin. Mean (± S.D.) tissue/serum concentration ratios were (mg/kg): parietal fat during opening 1.40 ± 1.05, during closure 1.34 ± 1.17, in the dura mater 2.26 ± 1.36, in skull bone during opening 0.44 ± 0.29, during closure 0.97 ± 1.57 and in brain tissue 0.88 ± 0.99. Mean (± S.D.) concentrations of ciprofloxacin in brain tissue were 0.87 ± 0.08 mg/kg, suggesting that a dose >200 mg iv ciprofloxacin is required to ensure therapeutic concentrations in brain tissue.

* Correspondence address. Service de Réanimation Polyvalente, Hôpital Nord, 13915 Marseille cedex 20, France. Tel: +33-4-91968650; Fax: +33-4-91962818; E-mail: marc.leone{at}ap-hm.fr


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