Skip Navigation


JAC Advance Access originally published online on September 6, 2002
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
50/4/547    most recent
dkf159v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (5)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Tominaga, K.
Right arrow Articles by Arakawa, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tominaga, K.
Right arrow Articles by Arakawa, T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


Journal of Antimicrobial Chemotherapy (2002) 50, 547-552
© 2002 The British Society for Antimicrobial Chemotherapy

In vivo action of novel alkyl methyl quinolone alkaloids against Helicobacter pylori

Kazunari Tominaga1,*, Kazuhide Higuchi1, Norio Hamasaki1, Masaki Hamaguchi1, Takashi Takashima1, Tetsuya Tanigawa1, Toshio Watanabe1, Yasuhiro Fujiwara1, Yasuhiro Tezuka2, Takema Nagaoka2, Shigetoshi Kadota2, Eiji Ishii3, Kazuo Kobayashi4 and Tetsuo Arakawa1

Departments of 1 Gastroenterology and 4 Host Defense, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585; 2 Research Institute for Traditional Sino-Japanese Medicines, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930-0194; 3 Department of Health and Epidemiology, Osaka City Institute of Public Health and Environmental Sciences, 8-34 Tohjo-cho, Tennoji-ku, Osaka 543-0026, Japan

Received 14 February 2002; returned 30 April 2002; revised 6 June 2002; accepted 21 June 2002

Previously purified and isolated compounds of novel alkyl methyl quinolone alkaloids (AM quinolones) from Gosyuyu (Wu-Chu-Yu), a Chinese herbal medicine, have a strong and highly selective antibacterial activity against Helicobacter pylori in vitro. To clarify the antibacterial mechanism(s) of AM quinolones, we examined the effects of AM quinolones on respiration of H. pylori in vitro. One week after treatment with AM quinolones alone (2, 10 or 20 mg/kg/day, orally) or combinations of AM quinolones and omeprazole (30 mg/kg/day) for H. pylori (1 x 108 cfu)-infected Mongolian gerbils, we checked viable H. pylori and myeloperoxidase (MPO) activity in the gastric tissues. AM quinolones decreased the number of H. pylori and inhibited H. pylori respiration in a dose-dependent manner. AM quinolones decreased the number of viable H. pylori (AM quinolones alone: 46.0 ± 22.6 x 104, 17.3 ± 4.9 x 104 and 8.1 ± 6.6 x 104 cfu/stomach, respectively; and combinations of AM quinolones and omeprazole: 8.0 ± 5.6 x 104, 4.2 ± 2.5 x 104 and 5.5 ± 2.7 x 104 cfu/stomach) compared with the vehicle-treated group (control: 359.9 ± 180.3 x 104 cfu/stomach). AM quinolones significantly decreased MPO activity of H. pylori-inoculated gastric tissues. These findings suggest that AM quinolones have a potent antibacterial effect against H. pylori through respiratory inhibition, and reduced bacterial growth in vivo. AM quinolones might be novel therapeutic agents for H. pylori eradication.

Keywords: H. pylori, alkyl methyl quinolones, eradication, respiration

* Corresponding author. Tel: +81-6-6645-3811; Fax: +81-6-6645-3813; E-mail: tomy{at}med.osaka-cu.ac.jp


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Evid Based Complement Alternat MedHome page
K. Tominaga, T. Kido, M. Ochi, C. Sadakane, A. Mase, H. Okazaki, H. Yamagami, T. Tanigawa, K. Watanabe, T. Watanabe, et al.
The Traditional Japanese Medicine Rikkunshito Promotes Gastric Emptying via the Antagonistic Action of the 5-HT3 Receptor Pathway in Rats
Evid. Based Complement. Altern. Med., October 27, 2009; (2009) nep173v1.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
D. Wu and Z. Hu
Rutaecarpine Induces Chloride Secretion across Rat Isolated Distal Colon
J. Pharmacol. Exp. Ther., April 1, 2008; 325(1): 256 - 266.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.