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Journal of Antimicrobial Chemotherapy (2002) 50, 411-420
© 2002 The British Society for Antimicrobial Chemotherapy

Comparative in vitro activity of faropenem and 11 other antimicrobial agents against 405 aerobic and anaerobic pathogens isolated from skin and soft tissue infections from animal and human bites

Ellie J. C. Goldstein*, Diane M. Citron, C. Vreni Merriam, Yumi A. Warren, Kerin L. Tyrrell and Helen T. Fernandez

R. M. Alden Research Laboratory, Santa Monica-UCLA Medical Center, Santa Monica, CA 90404 and the UCLA School of Medicine, Los Angeles, CA 90073, USA

Received 1 May 2002; returned 28 May 2002; revised 6 June 2002; accepted 7 June 2002

Faropenem, a new oral ß-lactam agent with a penem structure, was very active against 405 aerobic and anaerobic bite isolates. It inhibited 232 of 236 (98%) aerobic isolates, including all Pasteurella spp. and Eikenella corrodens at <=0.25 mg/L, and 164/169 (97%) anaerobic isolates, at <=1 mg/L. The 10 isolates that required >=2 mg/L for inhibition were one strain each of Acinetobacter lwoffi, Corynebacterium minutissimum, Bacteroides ovatus, Lactobacillus delbrueckii and Peptostreptococcus tetradius, plus Corynebacterium ‘aquaticum’ (two strains) and Veillonella sp. (three strains).

Keywords: faropenem, bite wounds, Pasteurella, anaerobes, cellulitis

* Correspondence address. 2021 Santa Monica Blvd, Suite 740 East, Santa Monica, CA 90404, USA. Tel: +1-310-315-1511; Fax: +1-310-3153662; E-mail: EJCGMD{at}aol.com


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