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Journal of Antimicrobial Chemotherapy (2002) 50, 403-406
© 2002 The British Society for Antimicrobial Chemotherapy

Genotypic characterization of macrolide-resistant strains of Streptococcus pneumoniae isolated in Quebec, Canada, and in vitro activity of ABT-773 and telithromycin

K. Weiss1,*, C. Guilbault1, L. Cortes1, C. Restieri1, D. E. Low and the EQUERE project (Etude QUEbecoise des pathogènes REspiratoires)2,§

1 Hôpital Maisonneuve-Rosemont, 5415 L’Assomption, Montreal, Quebec H1T 2M4; 2 Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada

Received 2 January 2002; returned 21 March 2002; revised 30 May 2002; accepted 13 June 2002

Increasing resistance of Streptococcus pneumoniae to macrolides represents a challenge for clinicians. New ketolides have an enhanced activity against macrolide-resistant strains. Four hundred and seventy-four strains of S. pneumoniae were collected during the 2000–2001 season in Quebec through a surveillance network. Macrolide resistance was 20.2%, and significantly higher in non-invasive strains versus invasive ones (22.4% versus 14.8%), and in children (30%) versus adults (14.8%). For susceptible strains, MIC90s of ABT-773 and telithromycin were 0.008 and 0.015 mg/L. Among the 96 macrolide-resistant strains, 56 (58%) were erm(B), 35 (37%) carried the mef(A) gene, four were carrying both genes and one none. ABT-773 and telithromycin were very active against all these resistant strains irrespective of the resistance mechanism, with MIC90s of 0.25 and 0.5 mg/L, respectively.

* Corresponding author. Tel: +1-514-252-3817; Fax: +1-514-252-3898; E-mail: weisscan{at}aol.com

§ The EQUERE project participants are listed in the Acknowledgements.


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