Journal of Antimicrobial Chemotherapy (2002) 50, 393-396
© 2002 The British Society for Antimicrobial Chemotherapy
Ceftazidime-hydrolysing CTX-M-15 extended-spectrum ß-lactamase (ESBL) in Poland
1 Sera and Vaccines Central Research Laboratory, ul. Cheßmska 30/34, 00-725 Warsaw, Poland; 2 Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique-Hôpitaux de Paris, Faculté de Médecine Paris-Sud, 78 rue du Général Leclerc, 94275 Le Kremlin-Bicêtre, France
Received 17 May 2002; returned 7 June 2002; revised 12 June 2002; accepted 14 June 2002
The CTX-M-15 extended-spectrum ß-lactamase (ESBL) was recently identified in Enterobacteriaceae isolates in India, and demonstrated significant hydrolytic activity against ceftazidime, in contrast to the majority of CTX-M enzymes. CTX-M-15 differs from CTX-M-3, which is one of the most prevalent ESBLs in Poland, by only a single amino acid change (Asp-240
Gly). Three cefotaxime- and ceftazidime-resistant Enterobacteriaceae isolates, recovered during 1998–2000 in two Polish hospitals, were found to produce CTX-M-15. Similar to those from India, the isolates contained the ISEcp1 insertion sequence located upstream of the blaCTX-M-15 gene, which has been recently demonstrated to mobilize 3'-adjacent genes to transfer between DNA replicons. However, its different position with respect to the ß-lactamase gene indicated the independent selection of the ESBL gene in the two countries.
Keywords: lactamases, ceftazidime, Enterobacteriaceae
* Corresponding author. Fax: +48-22-841-29-49; E-mail: gniadkow{at}cls.edu.pl
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