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Journal of Antimicrobial Chemotherapy (2002) 50, 289-292
© 2002 The British Society for Antimicrobial Chemotherapy

Inhibitory effect of roxithromycin on the local levels of bone-resorbing cytokines in an experimental model of murine osteomyelitis

Takashi Yoshii1,2,*, Shinya Magara2, Daisuke Miyai2, Eiji Kuroki2, Hidetaka Nishimura2, Shungo Furudoi2 and Takahide Komori2

1 Department of Dentistry, Hyogo Prefectural Staff Health Center, 5-10-1, Shimoyamate-dori, Chuo-ku, Kobe 650-8567; 2 Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan

Received 16 November 2001; returned 21 March 2002; revised 15 April 2002; accepted 22 May 2002

Objectives: The purpose of this study was to evaluate the inhibitory effect of roxithromycin on the production of interleukin (IL)-1ß, IL-6 and tumour necrosis factor-{alpha} (TNF-{alpha}) in a murine tibial osteomyelitis model using Staphylococcus aureus.

Methods: Cytokine levels in supernatants derived from bone homogenates were measured by enzyme-linked immunosorbent assay for 28 days, after oral administration of roxithromycin at 5 mg/kg/day.

Results: There was no significant difference in IL-6 levels between a group receiving roxithromycin administration and a group not receiving roxithromycin. IL-1ß and TNF-{alpha} levels were significantly lower for the administration group after 7–14 days and after 21–28 days, respectively. However, a significant difference in bacterial counts in bone between the groups was not observed.

Conclusion: These results indicate that roxithromycin suppresses the local expression of IL-1ß and TNF-{alpha}, and may exhibit an anti-inflammatory effect in this osteomyelitis model.

* Corresponding author. Tel: +81-78-362-3824; Fax: +81-78-362-4470; E-mail: takashi3{at}basil.ocn.ne.jp


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