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Journal of Antimicrobial Chemotherapy (2002) 50, 285-288
© 2002 The British Society for Antimicrobial Chemotherapy

Localization of [14C]clarithromycin in rat gastric tissue when administered with lansoprazole and amoxicillin

H. Endo1,*, H. Yoshida1, N. Ohmi1, K. Ohta1, S. Higuchi1 and T. Suga2

1 Department of Drug Metabolism, Research Center, Taisho Pharmaceutical Co., Ltd, 403 Yoshino-cho 1-chome, Saitama-shi, Saitama 330-8530; 2 Department of Clinical Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan

Received 22 October 2001; returned 7 February 2002; revised 14 March 2002; accepted 30 April 2002

After oral and intravenous administration of [14C]clarithromycin to rats, c. 60–70% of the radioactivity in the gastric tissue was found to be distributed in the mucosal layer. Co-administration of lansoprazole and amoxicillin had no apparent effect on this distribution pattern of [14C]clarithromycin. The amount of unchanged [14C]clarithromycin in gastric contents increased with co-administration of lansoprazole and amoxicillin. Microautoradiograms of the gastric mucosa showed that [14C]clarithromycin was highly distributed in the mucous layer and in surface epithelial cells following oral administration. Homogeneous distribution of radioactivity was evident in the fundic gland. With iv administration, [14C]clarithromycin seemed to be secreted by both secreting cells in the gland base and surface epithelial cells.

* Corresponding author. Tel: +81-48-669-3036; Fax: +81-48-652-7254; E-mail: hiromi.endou{at}po.rd.taisho.co.jp


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