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Journal of Antimicrobial Chemotherapy (2002) 50, 277-280
© 2002 The British Society for Antimicrobial Chemotherapy

Comparative in vitro activity of faropenem against staphylococci

Christof von Eiff*, Sven Schepers and Georg Peters

Institute of Medical Microbiology, University of Münster, Domagkstraße 10, 48149 Münster, Germany

Received 21 December 2001; returned 28 February 2002; revised 9 April 2002; accepted 29 April 2002

The anti-staphylococcal activity of faropenem, a novel ß-lactam, was examined and compared with that of amoxicillin, cefuroxime, clindamycin and vancomycin using the agar dilution method. A total of 234 staphylococci, including a large number of clonally different methicillin-resistant strains and a representative number of Staphylococcus aureus small colony variants, were tested. While the activity of faropenem was independent of the staphylococcal phenotype, the novel penem was up to eight times more active against methicillin-susceptible strains compared with the other agents tested. In addition, faropenem was active against many methicillin-resistant strains of S. aureus and coagulase-negative staphylococci.

* Corresponding author. Tel: +49-251-835-5360; Fax: +49-251-835-5350; E-mail: eiffc{at}uni-muenster.de


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 The Annals of PharmacotherapyHome page
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Ann. Pharmacother., January 1, 2008; 42(1): 80 - 90.
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