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Journal of Antimicrobial Chemotherapy (2002) 50, 265-269
© 2002 The British Society for Antimicrobial Chemotherapy

Influence of taxonomic status on the in vitro antimicrobial susceptibility of the Burkholderia cepacia complex

Sazini Nzula1, Peter Vandamme2 and John R. W. Govan1,*

1 Department of Medical Microbiology, The University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK; 2 Laboratorium voor Microbiologie, Universiteit Gent, K. L. Ledeganckstraat 35, B-9000 Gent, Belgium

Received 8 October 2001; returned 24 January 2002; revised 25 March 2002; accepted 6 June 2002

The Burkholderia cepacia complex is a diverse group of human pathogens that cause life-threatening lung infections in patients with cystic fibrosis or chronic granulomatous disease, and in patients requiring intensive care. Most previous antimicrobial susceptibility studies of these bacteria were performed before recent major revisions in the taxonomy of these bacteria. We determined the in vitro susceptibility of 65 B. cepacia complex isolates from clinical and environmental sources, representing six genomovars. Although intrinsic resistance is considered to be a common feature of the B. cepacia complex, MICs of individual antimicrobials varied widely and resistance was not exhibited by all members of the group.

* Corresponding author. Tel: +44-131-650-3164; Fax: +44-131-650-6653; E-mail: john.r.w.govan{at}ed.ac.uk


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