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Journal of Antimicrobial Chemotherapy (2002) 50, 261-264
© 2002 The British Society for Antimicrobial Chemotherapy

Distribution of ß-lactamases in Acinetobacter baumannii clinical isolates and the effect of Syn 2190 (AmpC inhibitor) on the MICs of different ß-lactam antibiotics

Cristina Danes, Margarita M. Navia, Joaquim Ruiz, Francesc Marco, Angels Jurado, M. Teresa Jimenez de Anta and Jordi Vila*

Servei de Microbiologia, Institut Clínic Infeccions i Immunologia (ICII), Hospital Clínic-IDIBAPS, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain

Received 19 September 2001; returned 28 December 2001; revised 28 February 2002; accepted 21 April 2002

The distribution of ß-lactamases in a group of 20 epidemiologically well defined Acinetobacter baumannii clinical isolates and the in vitro activity of Syn 2190, a novel ß-lactamase AmpC inhibitor, were determined. Twenty-five per cent of the strains carried and expressed a TEM-type ß-lactamase, whereas 35% had an OXA-type ß-lactamase. In nine out of 11 (82%) ceftazidime-resistant and four out of 13 (30.7%) cefepime-resistant strains, the MIC of these ß-lactam antibiotics decreased when determined in the presence of Syn 2190. Thus, our results suggest that in a high percentage of A. baumannii clinical isolates the increased production of AmpC, in combination or not with other resistance mechanisms, contributes to the resistance pattern in A. baumannii to ß-lactams.

* Corresponding author. Tel: +34-93-2275522; Fax: +34-93-2275454; E-mail: vila{at}medicina.ub.es


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