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Journal of Antimicrobial Chemotherapy (2002) 50, 115-117
© 2002 The British Society for Antimicrobial Chemotherapy

Susceptibility testing of Aspergillus spp. by means of an automated blood culture system

P.-M. Rath*, J. M. Freise and R. Ansorg

Institut für Medizinische Mikrobiologie, Universitätsklinikum Essen, Hufelandstrasse 55, D-45122 Essen, Germany

Received 4 July 2001; returned 28 November 2001; revised 14 January 2002; accepted 27 March 2002

The BacT/Alert blood culture system was evaluated for the MIC determination of amphotericin B for 27 strains of Aspergillus from five different species. An inoculum of c. 108 cfu/mL and an incubation time of 48 h resulted in MICs for 26 of 27 strains that corresponded with published MICs obtained in a microdilution assay. Twelve of 13 strains with MIC48 values >=2 mg/L showed growth within 24 h in bottles containing 0.25 mg/L amphotericin B, indicating that results can be obtained the day following inoculation. It is concluded that the BacT/Alert blood culture system can be used for susceptibility testing of Aspergillus spp. with amphotericin B.

* Corresponding author. Tel: +49-201-3538; Fax: +49-201-5729; E-mail: rath{at}uni-essen.de


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