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Journal of Antimicrobial Chemotherapy (2002) 50, 101-105
© 2002 The British Society for Antimicrobial Chemotherapy

Anti-anaerobic activity of AZD2563, a new oxazolidinone, compared with eight other agents

Lois M. Ednie1, Michael R. Jacobs2 and Peter C. Appelbaum1,*

1 Department of Pathology, Hershey Medical Center, 500 University Drive, Hershey, PA 17033; 2 Department of Pathology, Case Western Reserve University, Cleveland, OH, USA

Received 2 January 2002; returned 13 March 2002; revised 26 March 2002; accepted 13 April 2002

The anti-anaerobic activity of AZD2563, a new oxazolidinone, was compared with that of eight other agents against 201 Gram-positive and 99 Gram-negative anaerobes. MIC50 and MIC90 values (mg/L) for the 201 Gram-positive organisms were as follows: AZD2563, 1.0/4.0; linezolid, 1.0/4.0; quinupristin/dalfopristin, 0.5/1.0; amoxicillin, 0.25/1.0; clindamycin, 0.25/8.0; metronidazole, 0.5/>16.0; vancomycin, 0.5/2.0; teicoplanin, 0.125/0.25; and meropenem, 0.06/1.0. AZD2563, linezolid, vancomycin, teicoplanin and quinupristin/dalfopristin were mainly active against Gram-positive anaerobes, with no useful activity against Gram-negative anaerobes.

* Corresponding author. Tel: +1-717-531-5113; Fax: +1-717-531-7953; E-mail: pappelbaum{at}psu.edu


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