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Journal of Antimicrobial Chemotherapy (2002) 49, 1027-1030
© 2002 The British Society for Antimicrobial Chemotherapy

Effects of quinupristin/dalfopristin on vasomotor tone in the intact peripheral microcirculation

Takaya Tsueshita1,2, Salil Gandhi3 and Israel Rubinstein1,2,3,*

Departments of 1Medicine and 3Pharmaceutics and Pharmacodynamics, Colleges of Medicine and Pharmacy, University of Illinois at Chicago; 2Chicago VA Health Care System, West Side Division, Chicago, IL 60612, USA

Received 18 October 2001; returned 19 January 2002; revised 13 February 2002; accepted 6 March 2002.

The purpose of this study was to determine whether quinupristin/dalfopristin modulates vasomotor tone in the intact peripheral microcirculation. Using intravital microscopy, we found that superfusion of quinupristin/dalfopristin (120 mg/L) on the intact hamster cheek pouch microcirculation had no significant effects on arteriolar diameter. In addition, superfusion of quinupristin/dalfopristin (120 mg/L) had no significant effects on vasodilation evoked by bradykinin and acetylcholine, two endothelium-dependent agonists, or by vasoactive intestinal peptide, an endothelium-independent agonist, on to the cheek pouch. Collectively, these data indicate that quinupristin/dalfopristin has no significant effects on vasomotor tone in the intact peripheral microcirculation.

* Correspondence address. Department of Medicine (M/C 719), University of Illinois at Chicago, 840 S. Wood Street, Chicago, IL 60612-7323, USA. Tel: +1-312-996-8039; Fax: +1-312-996-4665; E-mail: IRubinst{at}uic.edu


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