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Journal of Antimicrobial Chemotherapy (2002) 49, 871-874
© 2002 The British Society for Antimicrobial Chemotherapy

Evaluation of two inhibitors of invasion: LY311727 [3-(3-acetamide-1-benzyl-2-ethyl-indolyl-5-oxy)propane phosphonic acid] and AEBSF [4-(2-aminoethyl)-benzenesulphonyl fluoride] in acute murine toxoplasmosis

Rafael Buitrago-Rey1,2, Jorge Olarte2 and Jorge Enrique Gomez-Marin1,3,*

1Facultad de Medicina; 2Posgrado de Farmacología, Facultad de Ciencias, Universidad Nacional de Colombia; 3Centro de Investigaciones Biomedicas, Facultad de Ciencias de la Salud, Universidad del Quindio, Armenia (Q), Colombia

Received 23 July 2001; returned 18 November 2001; revised 18 December 2001; accepted 23 January 2002.

We examined the effect of an inhibitor of secretory phospholipase A2 type II (LY311727) and of a specific inhibitor of serine proteases (AEBSF) in a murine model of acute toxoplasmosis. LY311727 did not afford any significant protection and produced earlier mortality compared with untreated mice at a dose of 100 mg/kg. In contrast, AEBSF demonstrated a significant increase in length of survival, and this effect was enhanced when AEBSF was administered with non-protective doses of pyrimethamine.

* Corresponding author. Tel/Fax: +57-674-60168; E-mail: jegomezmarin{at}hotmail.com


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