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Journal of Antimicrobial Chemotherapy (2002) 49, 867-870
© 2002 The British Society for Antimicrobial Chemotherapy

Effect of clarithromycin on chronic respiratory infection caused by Pseudomonas aeruginosa with biofilm formation in an experimental murine model

Katsunori Yanagihara,*, Kazunori Tomono, Yoshifumi Imamura, Yukihiro Kaneko, Misuzu Kuroki, Toyomitsu Sawai, Yoshitsugu Miyazaki, Yoichi Hirakata, Hiroshi Mukae, Jun-Ichi Kadota and Shigeru Kohno

The Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852, Japan

Received 10 September 2001; returned 4 December 2001; revised 3 January 2002; accepted 22 January 2002.

Fourteen-membered macrolides (e.g. clarithromycin and erythromycin), but not 16-membered macrolides (e.g. josamycin), are effective in diffuse panbronchiolitis. However, there are no studies that have compared the effects of 14- and 16-membered macrolide antibiotics on biofilm formation. Treatment with high-dose clarithromycin (100 mg/kg) resulted in a significant decrease in the number of viable bacteria in an experimental murine model. Josamycin at a dose of up to 100 mg/kg had no effect on the number of viable bacteria in the lung. Our results may explain, at least in part, the clinical efficacy of 14-membered macrolide antibiotics in patients with chronic pneumonia caused by Pseudomonas aeruginosa.

Keywords: macrolide antibiotics, chronic respiratory infection, Pseudomonas aeruginosa, biofilm formation, murine model

* Corresponding author. Tel: +81-95-849-7276; Fax: +81-95-849-7285; E-mail: kyana-ngs{at}umin.ac.jp


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