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Journal of Antimicrobial Chemotherapy (2002) 49, 863-866
© 2002 The British Society for Antimicrobial Chemotherapy

Antibiotic tolerance of peritoneal bacterial isolates in dialysis fluids

Sheryl Zelenitsky1,4,*, Christine Franczuk1, Adrian Fine2,5, Robert Ariano1,3 and Godfrey Harding2,4

Faculties of 1Pharmacy and 2Medicine, University of Manitoba; Departments of 3Pharmacy, 4Infectious Diseases and 5Nephrology, St Boniface General Hospital, Winnipeg, Manitoba, Canada

Received 6 August 2001; returned 19 November 2001; revised 17 December 2001; accepted 23 January 2002.

The objective was to test antibiotic activity against Staphylococcus epidermidis and Pseudomonas aeruginosa in fresh dianeal fluid and spent dialysate from patients undergoing chronic ambulatory peritoneal dialysis. MICs and MBCs were measured and compared with those in standard broth. For S. epidermidis, there was some reduction in cefazolin and vancomycin activity in dialysis fluids. For P. aeruginosa, ciprofloxacin and tobramycin MICs increased significantly, and all isolates were tolerant to ceftazidime and piperacillin in dialysis fluids. Dialysis fluids can significantly impair antibiotic activity. The clinical implications warrant further study of antibiotic pharmacodynamics in the treatment of peritonitis.

* Corresponding author. Tel: +1-204-474-8414; Fax: +1-204-474-7617; E-mail: Zelenits{at}ms.umanitoba.ca


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