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Journal of Antimicrobial Chemotherapy (2002) 49, 857-861
© 2002 The British Society for Antimicrobial Chemotherapy

Intracellular activity of ABT-773 and other antimicrobial agents against Legionella pneumophila

Rose Jung1, Larry H. Danziger2 and Susan L. Pendland2,*

1Department of Pharmacy Practice, University of Colorado Health Science Center, Denver, CO; 2Microbiology Research Laboratory, Department of Pharmacy Practice, The University of Illinois at Chicago, Chicago, IL, USA

Received 2 July 2001; returned 31 October 2001; revised 2 January 2002; accepted 1 February 2002.

The intracellular activity of ABT-773 against Legionella pneumophila was compared with azithromycin and ciprofloxacin using HL-60 cells. Against L. pneumophila ATCC 33152 and three clinical isolates the MICs (mg/L) were ABT-773 0.015, ciprofloxacin 0.03 and azithromycin 0.03. At 48 h, the mean percentage inhibition was as follows: 28.5 ± 5.9% and 32.6 ± 4.6% at 8 x and 16 x MIC of ABT-773; 38.1 ± 8.6% and 48.2 ± 7.0% at 8 x and 16 x MIC of ciprofloxacin; and 26.3 ± 9.9% and 28.5 ± 9.9% at 8 x and 16 x MIC of azithromycin. In this study, all three agents were highly active, with ABT-773 demonstrating similar activity to azithromycin against L. pneumophila.

* Correspondence address. The University of Illinois at Chicago, College of Pharmacy, Department of Pharmacy Practice (M/C 886), 833 South Wood Street, Chicago, IL 60612, USA. Tel: +1-312-996-8639; Fax: +1-312-413-1797; E-mail: Pendland{at}uic.edu


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