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Journal of Antimicrobial Chemotherapy (2002) 49, 845-850
© 2002 The British Society for Antimicrobial Chemotherapy

In vitro activity of a new cephalosporin, RWJ-54428, against streptococci, enterococci and staphylococci, including glycopeptide-intermediate Staphylococcus aureus

Jana M. Swenson* and Fred C. Tenover

Anti-infectives Investigation Section, Epidemiology and Laboratory Branch, Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Mailstop G08, 1600 Clifton Road N.E., Atlanta, GA 30333, USA

Received 23 October 2001; returned 6 December 2001; revised 24 January 2002; accepted 5 February 2002.

The need for new antimicrobial agents with activity against Gram-positive organisms has become increasingly important because of emerging resistance. We compared the activity of a new b-lactam antimicrobial agent, RWJ-54428 (MC-02 479), with representatives of other classes of antimicrobial agents against 76 Staphylococcus aureus (including four glycopeptide- intermediate strains), 50 coagulase-negative staphylococci, 20 Enterococcus faecalis, 20 Enterococcus faecium, 10 Enterococcus gallinarum/Enterococcus casseliflavus, 54 Streptococcus pneumoniae and 22 viridans streptococcal isolates. The MIC90 of RWJ-54428 was <=2 mg/L for all groups of bacteria tested except E. faecium. The activity against four strains of glycopeptide-intermediate S. aureus was similar to that for other methicillin-resistant S. aureus isolates (range 0.5–2.0 mg/L).

* Corresponding author. Tel: +1-404-639-0196; Fax: +1-404-639-1381; E-mail: jms1{at}cdc.gov


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