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Journal of Antimicrobial Chemotherapy (2002) 49, 741-744
© 2002 The British Society for Antimicrobial Chemotherapy

In vitro susceptibilities of Zygomycota to polyenes

Eric Dannaoui1, Jacques F. G. M. Meis2, Johan W. Mouton2, Paul E. Verweij and the Eurofung Network1,*,§

1Department of Medical Microbiology, University Medical Center St Radboud, PO Box 9101, 6500 HB Nijmegen; 2Canisius-Wilhelmina Hospital, PO Box 9015, 65000 GS Nijmegen, The Netherlands

Received 17 September 2001; returned 14 December 2001; revised 14 January 2002; accepted 27 January 2002.

The in vitro activity of polyenes was determined for 36 isolates of Zygomycota including Rhizopus spp. (15), Absidia corymbifera (10), Mucor spp. (6), Rhizomucor spp. (3), Cunninghamella bertholletiae (1) and Apophysomyces elegans (1). All isolates were tested with amphotericin B, heated amphotericin B and nystatin by a broth microdilution test. There were no significant differences between heated and unheated solutions of amphotericin B in terms of their antifungal activities. The MICs of amphotericin B for most of the strains were <2 mg/L. For all isolates, nystatin was significantly less active than amphotericin B (P < 0.001). The one C. bertholletiae and one A. elegans isolates were less susceptible to amphotericin B (MICs 2 mg/L) and were also less susceptible to nystatin.

* Corresponding author. Tel: +31-24-361-42 56; Fax: +31-24-354-02-16; E-mail: p.verweij{at}mmb.azn.nl

§ Members are listed in the Acknowledgements.


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