Journal of Antimicrobial Chemotherapy (2002) 49, 683-687
© 2002 The British Society for Antimicrobial Chemotherapy
Brief report |
Alcoholic ingredients in skin disinfectants increase biofilm expression of Staphylococcus epidermidis
Institut für Medizinische Mikrobiologie und Immunologie, Universitätsklinikum Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany
The pathogenesis of Staphylococcus epidermidis is correlated with biofilm formation. We investigated the effect of three common alcoholic skin disinfectants, ethanol, n-propanol and isopropanol, on the biofilm formation of 37 clinical, icaADBC-positive S. epidermidis isolates. In alcohol-supplemented media 18 strains displayed increased biofilm expression. Sixteen of 19 strains were generally incapable of biofilm formation. In three representative isolates, the increase in biofilm formation was paralleled by increased polysaccharide intercellular adhesin synthesis. Regarding the widespread use of alcoholic skin disinfectants, it is possible that the alcohol-inducible biofilm phenotype of S. epidermidis could add to the development of foreign body-related infections.
* Corresponding author. Tel: +49-40-42803-3147; Fax: +49-40-42803-4881; E-mail: knobloch{at}uke.uni-hamburg.de
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  T. Nuryastuti, H. C. van der Mei, H. J. Busscher, S. Iravati, A. T. Aman, and B. P. Krom Effect of Cinnamon Oil on icaA Expression and Biofilm Formation by Staphylococcus epidermidis Appl. Envir. Microbiol., November 1, 2009; 75(21): 6850 - 6855. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Frank and R. Patel Poly-N-Acetylglucosamine Is Not a Major Component of the Extracellular Matrix in Biofilms Formed by icaADBC-Positive Staphylococcus lugdunensis Isolates Infect. Immun., October 1, 2007; 75(10): 4728 - 4742. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. K. Mukherjee, S. Mohamed, J. Chandra, D. Kuhn, S. Liu, O. S. Antar, R. Munyon, A. P. Mitchell, D. Andes, M. R. Chance, et al. Alcohol Dehydrogenase Restricts the Ability of the Pathogen Candida albicans To Form a Biofilm on Catheter Surfaces through an Ethanol-Based Mechanism Infect. Immun., July 1, 2006; 74(7): 3804 - 3816. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Chatterjee, G. A. Somerville, C. Heilmann, H.-G. Sahl, H. H. Maurer, and M. Herrmann Very Low Ethanol Concentrations Affect the Viability and Growth Recovery in Post-Stationary-Phase Staphylococcus aureus Populations Appl. Envir. Microbiol., April 1, 2006; 72(4): 2627 - 2636. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Jager, D. Mack, H. Rohde, M. A. Horstkotte, and J. K.-M. Knobloch Disintegration of Staphylococcus epidermidis Biofilms under Glucose-Limiting Conditions Depends on the Activity of the Alternative Sigma Factor {sigma}B Appl. Envir. Microbiol., September 1, 2005; 71(9): 5577 - 5581. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gravesen, C. Lekkas, and S. Knochel Surface Attachment of Listeria monocytogenes Is Induced by Sublethal Concentrations of Alcohol at Low Temperatures Appl. Envir. Microbiol., September 1, 2005; 71(9): 5601 - 5603. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Sadovskaya, E. Vinogradov, S. Flahaut, G. Kogan, and S. Jabbouri Extracellular Carbohydrate-Containing Polymers of a Model Biofilm-Producing Strain, Staphylococcus epidermidis RP62A Infect. Immun., May 1, 2005; 73(5): 3007 - 3017. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. K.-M. Knobloch, S. Jager, J. Huck, M. A. Horstkotte, and D. Mack mecA Is Not Involved in the {sigma}B-Dependent Switch of the Expression Phenotype of Methicillin Resistance in Staphylococcus epidermidis Antimicrob. Agents Chemother., March 1, 2005; 49(3): 1216 - 1219. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Rohde, M. Kalitzky, N. Kroger, S. Scherpe, M. A. Horstkotte, J. K.-M. Knobloch, A. R. Zander, and D. Mack Detection of Virulence-Associated Genes Not Useful for Discriminating between Invasive and Commensal Staphylococcus epidermidis Strains from a Bone Marrow Transplant Unit J. Clin. Microbiol., December 1, 2004; 42(12): 5614 - 5619. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K.-M. Knobloch, S. Jager, M. A. Horstkotte, H. Rohde, and D. Mack RsbU-Dependent Regulation of Staphylococcus epidermidis Biofilm Formation Is Mediated via the Alternative Sigma Factor {sigma}B by Repression of the Negative Regulator Gene icaR Infect. Immun., July 1, 2004; 72(7): 3838 - 3848. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Lim, M. Jana, T. T. Luong, and C. Y. Lee Control of Glucose- and NaCl-Induced Biofilm Formation by rbf in Staphylococcus aureus J. Bacteriol., February 1, 2004; 186(3): 722 - 729. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K.-M. Knobloch, M. Nedelmann, K. Kiel, K. Bartscht, M. A. Horstkotte, S. Dobinsky, H. Rohde, and D. Mack Establishment of an Arbitrary PCR for Rapid Identification of Tn917 Insertion Sites in Staphylococcus epidermidis: Characterization of Biofilm-Negative and Nonmucoid Mutants Appl. Envir. Microbiol., October 1, 2003; 69(10): 5812 - 5818. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Dobinsky, K. Kiel, H. Rohde, K. Bartscht, J. K.-M. Knobloch, M. A. Horstkotte, and D. Mack Glucose-Related Dissociation between icaADBC Transcription and Biofilm Expression by Staphylococcus epidermidis: Evidence for an Additional Factor Required for Polysaccharide Intercellular Adhesin Synthesis J. Bacteriol., May 1, 2003; 185(9): 2879 - 2886. [Abstract] [Full Text] [PDF]
|
|