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Journal of Antimicrobial Chemotherapy (2002) 49, 557-560
© 2002 The British Society for Antimicrobial Chemotherapy

Brief report

The ACT-1 plasmid-encoded AmpC ß-lactamase is inducible: detection in a complex ß-lactamase background

Mark D. Reisbiga,b and Nancy D. Hansona,b,*

a Department of Medical Microbiology and Immunology and b Center for Research in Anti-Infectives and Biotechnology, Creighton University School of Medicine, Omaha, NE, USA

The purpose of this study was to identify the genetic organization and inducibility of blaACT-1 in a clinical isolate of Klebsiella pneumoniae possessing at least five different ß-lactamases. The genetic organization of the blaACT-1/ampR region is identical to those of inducible chromosomal ampC genes. RNA analysis using primer extension demonstrated a five-fold increase in blaACT-1 transcript production on exposure to cefoxitin. These findings are significant because induction was detected in a complicated ß-lactamase background. In addition, this report is the first to describe an inducible plasmid-encoded AmpC ß-lactamase of Enterobacter cloacae origin.

* Correspondence address. Center for Research in Anti-Infectives and Biotechnology, Department of Microbiology and Immunology, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA; Tel: +1-402-280-5837; Fax: +1-402-280-1875; E-mail: ndhanson{at}creighton.edu


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