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Journal of Antimicrobial Chemotherapy (2002) 49, 553-556
© 2002 The British Society for Antimicrobial Chemotherapy

Brief report

Non-PmrA-mediated multidrug resistance in Streptococcus pneumoniae

Ekaterina Pestovaa,*, John J. Millichapa, Farida Siddiquib, Gary A. Noskina,b and Lance R. Petersona

a Northwestern Prevention Epicenter, Division of Microbiology, Department of Pathology and b Division of Infectious Diseases, Department of Medicine, Northwestern University Medical School and Northwestern Memorial Hospital, Chicago, IL, USA

The PmrA multidrug transporter protein gene was inactivated in Streptococcus pneumoniae strains CP1000 (wild-type) and EBR (mutant with enhanced active multidrug efflux). While the resistance to fluoroquinolones and ethidium bromide shown by EBR was reduced to the wild-type level, neither the susceptibility to reserpine in the presence of ethidium bromide and selected fluoroquinolones, nor the ability to produce ethidium bromide-resistant mutants was eliminated in the CP1000 pmrA mutant, indicating the presence of an additional multidrug export protein(s).

* Correspondence address. Northwestern Prevention Epicenter, Galter Carriage House, Suite 701b, 215 East Chicago Avenue, Chicago, IL 60611, USA. Tel: +1-312-926-2885; Fax: +1-312-926–4139; E-mail: EPestova{at}vysis.com


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