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Journal of Antimicrobial Chemotherapy (2002) 49, 437-444
© 2002 The British Society for Antimicrobial Chemotherapy

Reviews

Role of aminoglycosides in the treatment of bacterial endocarditis

J. C. Graham,* and F. K. Gould

Microbiology Department, Freeman Hospital, High Heaton, Newcastle upon Tyne NE7 7DN, UK

Aminoglycosides are often used in combination with glycopeptides and ß-lactams for the treatment of bacterial endocarditis caused by {alpha}-haemolytic streptococci, staphylococci and enterococci. Recommendations on dosing and duration of aminoglycoside therapy vary; we detail the laboratory and clinical evidence base for the treatment regimens advised. A number of deficiencies in the published guidelines are highlighted, as is the limited evidence base upon which many of the regimens are recommended. With the increasing use of outpatient treatment of severe infections and once daily administration of aminoglycosides the opportunity should be taken for larger, multicentre clinical trials to evaluate formally both old and new regimens.

* Corresponding author. Tel: +44-191-284-3111; Fax: +44-191-223-1224; E-mail: j.c.graham{at}ncl.ac.uk


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