Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (19)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Graham, J. C.
Right arrow Articles by Gould, F. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Graham, J. C.
Right arrow Articles by Gould, F. K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of Antimicrobial Chemotherapy (2002) 49, 437-444
© 2002 The British Society for Antimicrobial Chemotherapy

Reviews

Role of aminoglycosides in the treatment of bacterial endocarditis

J. C. Graham,* and F. K. Gould

Microbiology Department, Freeman Hospital, High Heaton, Newcastle upon Tyne NE7 7DN, UK

Aminoglycosides are often used in combination with glycopeptides and ß-lactams for the treatment of bacterial endocarditis caused by {alpha}-haemolytic streptococci, staphylococci and enterococci. Recommendations on dosing and duration of aminoglycoside therapy vary; we detail the laboratory and clinical evidence base for the treatment regimens advised. A number of deficiencies in the published guidelines are highlighted, as is the limited evidence base upon which many of the regimens are recommended. With the increasing use of outpatient treatment of severe infections and once daily administration of aminoglycosides the opportunity should be taken for larger, multicentre clinical trials to evaluate formally both old and new regimens.

* Corresponding author. Tel: +44-191-284-3111; Fax: +44-191-223-1224; E-mail: j.c.graham{at}ncl.ac.uk


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J Antimicrob ChemotherHome page
M. E. Falagas, D. K. Matthaiou, and I. A. Bliziotis
The role of aminoglycosides in combination with a {beta}-lactam for the treatment of bacterial endocarditis: a meta-analysis of comparative trials
J. Antimicrob. Chemother., April 1, 2006; 57(4): 639 - 647.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
R. Zarrilli, M.-F. Tripodi, A. Di Popolo, R. Fortunato, M. Bagattini, M. Crispino, A. Florio, M. Triassi, and R. Utili
Molecular epidemiology of high-level aminoglycoside-resistant enterococci isolated from patients in a university hospital in southern Italy
J. Antimicrob. Chemother., November 1, 2005; 56(5): 827 - 835.
[Abstract] [Full Text] [PDF]

Home page
 The Annals of PharmacotherapyHome page
A C. Graham, R.-C. Mercier, L. E Achusim, and M. P Pai
Extended-Interval Aminoglycoside Dosing for Treatment of Enterococcal and Staphylococcal Osteomyelitis
Ann. Pharmacother., June 1, 2004; 38(6): 936 - 941.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
S. B. Vakulenko and S. Mobashery
Versatility of Aminoglycosides and Prospects for Their Future
Clin. Microbiol. Rev., July 1, 2003; 16(3): 430 - 450.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
D. Nathwani
From evidence-based guideline methodology to quality of care standards
J. Antimicrob. Chemother., May 1, 2003; 51(5): 1103 - 1107.
[Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.