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Journal of Antimicrobial Chemotherapy (2002) 49, 387-389
© 2002 The British Society for Antimicrobial Chemotherapy

Brief report

Differential regulation of L1 and L2 ß-lactamase expression in Stenotrophomonas maltophilia

Matthew B. Avison,*, Catherine S. Higgins, Peter J. Ford, Charlotte J. von Heldreich, Timothy R. Walsh and Peter M. Bennett

Bristol Centre for Antimicrobial Research and Evaluation, Department of Pathology and Microbiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UK

It has been reported that Stenotrophomonas maltophilia L1 and L2 ß-lactamase expression is coordinated. We have isolated S. maltophilia mutants where (i) L1 is constitutively hyper-expressed and L2 is inducible; (ii) L2 is hyper-expressed and L1 is inducible; and (iii) L1 and L2 are constitutively hyper-expressed. The frequency of isolating type 1 and 2 mutants is c. 10-7, indicating that promoter mutations are probably not involved and providing strong evidence that L1 and L2 expression is not, after all, coordinated. The frequency of isolating type 3 mutants is c. 10-9, however, implying that there is a significant overlap between the regulatory mechanisms.

* Correspondence address. Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK. Tel: +44-117-9287439; Fax: +44-117-9287896; E-mail: matthewb.avison{at}bris.ac.uk


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