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Journal of Antimicrobial Chemotherapy (2002) 49, 327-330
© 2002 The British Society for Antimicrobial Chemotherapy

Cefepime is efficacious against penicillin- and quinolone-resistant pneumococci in experimental meningitis

Philippe Cottagnouda,*, Fernando Acostab, Marianne Cottagnoudb and Martin G. Täuberc

a Department of Internal Medicine, Inselspital, 3010 Bern; b Department of Internal Medicine, Zieglerspital, 3007 Bern; c Institute for Infectious Diseases, University of Bern, 3010 Bern, Switzerland

In experimental rabbit meningitis, cefepime given at a dose of 100 mg/kg was associated with concentrations in the cerebrospinal fluid of between 5.3 and 10 mg/L and a bactericidal activity of -0.61 ± 0.24 {delta}log10 cfu/mL•h, similar to the standard regimen of ceftriaxone combined with vancomycin (-0.58 ± 0.14 {delta}log10 cfu/mL•h) in the treatment of meningitis due to a penicillin- and quinolone-resistant pneumococcal mutant strain (MIC 4 mg/L). Compared with the penicillin-resistant parental strain, the penicillin- and quinolone-resistant mutant was killed more slowly by cefepime and ceftriaxone in time-killing assays in vitro over 8 h.

* Corresponding author. Tel: +41-316-322-111; Fax: +41-316-323-847; E-mail: pcottagn{at}insel.ch


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