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Journal of Antimicrobial Chemotherapy (2002) 49, 315-320
© 2002 The British Society for Antimicrobial Chemotherapy

Phosphate deprivation is associated with high resistance to latamoxef of gel-entrapped, sessile-like Escherichia coli cells

Sébastien Vilain, Pascal Cosette, Guy-Alain Junter and Thierry Jouenne,*

UMR 6522 CNRS, IFRMP 23, Faculté des Sciences de Rouen, 76821 Mont-Saint-Aignan Cedex, France

Viable Escherichia coli cells were entrapped in agar gel layers and incubated in a phosphate-limited glucose medium. Immobilized bacteria displayed enhanced alkaline phosphatase activity and overexpressed the outer membrane protein PhoE as compared with free-floating organisms. These observations highlighted the existence of high phosphate deprivation within biofilm-like structures. In addition, the antimicrobial efficacy of latamoxef against immobilized bacteria was partly recovered in the presence of a high phosphate concentration. From these data, a possible role of phosphate deprivation in the high resistance of sessile-like organisms to antibiotics may be considered.

* Corresponding author. Tel: +33-2-35-14-66-80; Fax: +33-2-35-14-67-13; E-mail: thierry.jouenne{at}univ-rouen.fr


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