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Journal of Antimicrobial Chemotherapy (2002) 49, 189-192
© 2002 The British Society for Antimicrobial Chemotherapy

Brief report

Comparative in vitro activity of ABT-773 and two macrolides against staphylococci

Christof von Eiff,* and Georg Peters

Institute of Medical Microbiology, University of Münster Hospital and Clinics, 48149 Münster, Germany

The anti-staphylococcal activity of ABT-773, a new member of the ketolides, was examined and compared with those of erythromycin and clarithromycin using the agar dilution method. A total of 336 well-defined clinical isolates of staphylococci, including a large number of clonally different methicillin-resistant strains with defined macrolide-lincosamide-streptogramin B (MLSB) resistance phenotypes were tested. The novel ketolide exhibited broad-spectrum anti-staphylococcal activity against both methicillin-susceptible and methicillin-resistant strains. Apart from strains with constitutive expression of MLSB resistance, all staphylococcal strains tested were inhibited by <=0.063 mg/L of ABT-773, irrespective of the resistance phenotype for methicillin.

* Corresponding author. Tel: +49-251-835-5360; Fax: +49-251-835-5350; E-mail: eiffc{at}uni-muenster.de


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S. R. Pai, K. V. Singh, and B. E. Murray
In Vivo Efficacy of the Ketolide ABT-773 (Cethromycin) against Enterococci in a Mouse Peritonitis Model
Antimicrob. Agents Chemother., August 1, 2003; 47(8): 2706 - 2709.
[Abstract] [Full Text] [PDF]


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