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Journal of Antimicrobial Chemotherapy (2001) 48, 731-734
© 2001 The British Society for Antimicrobial Chemotherapy


Brief report

Emergence of extremely high penicillin and cefotaxime resistance and high-level levofloxacin resistance in clinical isolates of Streptococcus pneumoniae in Hungary

Katalin Glatza, Dóra Szabóa, György Szabób, Dimitrinka Boriszovac and Ferenc Rozgonyia,*

a Institute of Medical Microbiology, Semmelweis University, Box 370, H-1445 Budapest; b Phage Laboratory of the Budapest Institute of the National Public Health and Medical Officer Service, Budapest; c Pál Heim Municipal Children's Hospital of Budapest, Budapest, Hungary

Oxacillin disc diffusion tests revealed that 36.7% of 327 Hungarian Streptococcus pneumoniae strains from clinical specimens were not penicillin susceptible. Determination of the MICs of penicillin, cefotaxime and levofloxacin for these strains by Etest confirmed that 30 (9.2%), 19 (5.8%) and four to 11 (1.2–3.4%) were fully penicillin-, cefotaxime- and levofloxacin-resistant, respectively. Most had extremely high MICs. Lower respiratory tract strains were more resistant than those from the upper respiratory tract. Levofloxacin-resistant strains were either penicillin intermediate or resistant, but their MICs did not correlate strongly.

* Corresponding author. Tel/Fax: +36-1-210-2959; E-mail: rozfer{at}net.sote.hu


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