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Journal of Antimicrobial Chemotherapy (2001) 48, 717-721
© 2001 The British Society for Antimicrobial Chemotherapy

Brief report

OXA-35 is an OXA-10-related ß-lactamase from Pseudomonas aeruginosa

Daniel Auberta, Laurent Poirela, Adel Ben Alib, Fred W. Goldsteinb and Patrice Nordmanna,*

a Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, 94275 Le Kremlin-Bicêtre; b Laboratoire de Bactériologie, Hôpital Saint-Joseph, 75014 Paris, France

Pseudomonas aeruginosa clinical isolate PA35 is resistant to amino- and ureido-penicillins, has intermediate susceptibility to cefsulodin, cefepime and aztreonam, and is susceptible to imipenem and ceftazidime. Cloning and sequencing revealed a new ß-lactamase variant, OXA-35, sharing 96% amino acid identity with OXA-10. OXA-35 displays a restricted-substrate hydrolysis profile with improved hydrolysis of amoxicillin and cloxacillin compared with OXA-10. OXA-35 differs from derivatives OXA-19 and OXA-28 by one amino acid substitution and may be a progenitor of these OXA-13-like extended-spectrum ß-lactamases.

* Corresponding author. Tel: +33-1-45-21-36-32; Fax: +33-1-45-21-63-40; E-mail: nordmann.patrice{at}bct.ap-hop-paris.fr


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