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Journal of Antimicrobial Chemotherapy (2001) 48, 709-712
© 2001 The British Society for Antimicrobial Chemotherapy

Brief report

Comparative study of new benzenesulphonamide fluoroquinolones structurally related to ciprofloxacin against selected ciprofloxacin-susceptible and -resistant Gram-positive cocci

F. Aloveroa, A. Barnesa,b, M. Nietoa, M. R. Mazzieria and R. H. Manzoa,*

a Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, (5000) Ciudad Universitaria, Córdoba; b Hospital Tránsito Cáceres de Allende, Córdoba, Argentina

The in vitro activities of benzenesulphonamide fluoroquinolones (BSFQs) I–III, new fluoroquinolones with a p-substituted benzenesulphonyl moiety attached to the C7 piperazinyl ring of ciprofloxacin, were assessed in comparison with those of N-sulfanilylpiperazinyl fluoroquinolone (NSFQ)-105 and ciprofloxacin for 133 Gram-positive clinical isolates. NSFQ-105 and BSFQ-I were the most active drugs. They were 16- to 64-fold more active than ciprofloxacin against Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, including ciprofloxacin-resistant strains, and Streptococcus pneumoniae (eight- to 32-fold). A high degree of correlation was found between the MICs of the new compounds and ciprofloxacin for Staphylococcus spp. and E. faecalis. Staphylococci and enterococci exhibit cross-resistance to BSFQs and ciprofloxacin.

* Corresponding author. Tel/Fax: +54-351-4334127; E-mail: rubmanzo{at}dqo.fcq.unc.edu.ar


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