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Journal of Antimicrobial Chemotherapy (2001) 48, 583-586
© 2001 The British Society for Antimicrobial Chemotherapy

Brief report

Treatment of Absidia corymbifera infection in mice with amphotericin B and itraconazole

J. Mosqueraa, P. A. Warna, J. L. Rodriguez-Tudelab and D. W. Denninga,c,*

a School of Medicine, Section of Infectious Diseases, University of Manchester, Hope Hospital, Salford, Manchester M6 8HD, UK; b Servicio de Micologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain; c Department of Infectious Diseases and Tropical Medicine, North Manchester General Hospital, Delaunays Road, Manchester M8 6RB, UK

The activities of amphotericin B and itraconazole were studied in a temporarily neutropenic murine model of disseminated Absidia corymbifera infection, caused by two different strains. Amphotericin B MICs were 0.25 mg/L for both strains and itraconazole MICs were 1 and 2 mg/L. Amphotericin B was effective in vivo with both isolates. Itraconazole was less effective.

* Corresponding author. Tel: +44-161-720-2734; Fax: +44-161-720-2732; E-mail: ddenning{at}man.ac.uk


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