Journal of Antimicrobial Chemotherapy (2001) 48, 383-389
© 2001 The British Society for Antimicrobial Chemotherapy
CMY-2-producing Salmonella enterica, Klebsiella pneumoniae, Klebsiella oxytoca, Proteus mirabilis and Escherichia coli strains isolated in Spain (October 1999–December 2000)
a Microbiology Department, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma 08025 Barcelona; b Microbiology Department, Complejo Hospitalario Donostia, Universidad del País Vasco, Avenida Dr. Beguiristain s/n, 20014 San Sebastián, Spain
CMY-2 plasmid-mediated AmpC ß-lactamase (CMY-2) was detected in 21 isolates from two hospitals located in different geographical regions of Spain between October 1999 and December 2000. The isolates comprised two Salmonella enterica serovars (Mikawasima and Montevideo), 16 Escherichia coli, one Klebsiella pneumoniae, one Klebsiella oxytoca and one Proteus mirabilis. In addition to the expected resistance to ß-lactams, including extended-spectrum cephalosporins and cefoxitin, all isolates showed a broad spectrum of associated resistance. All were resistant to sulfamethoxazole, chloramphenicol, tetracycline and streptomycin, and all but two were also resistant to gentamicin. Five isolates were studied in detail and all transferred CMY-2 and other resistance determinants by conjugation. Genomic DNA restriction pattern analysis of the E. coli isolates excluded the dissemination of a single clone. To the best of our knowledge this is the first time that CMY-2 has been detected in P. mirabilis, K. oxytoca and S. enterica serovars Mikawasima and Montevideo. It is also the first time that CMY-2 has been described in Spain.
* Corresponding author. Tel: +34-943-00-70-46; Fax: +34-943-00-70-63; E-mail: labmikro{at}terra.es
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