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Journal of Antimicrobial Chemotherapy (2001) 48, 361-364
© 2001 The British Society for Antimicrobial Chemotherapy

Epigallocatechin gallate synergy with ampicillin/sulbactam against 28 clinical isolates of methicillin-resistant Staphylococcus aureus

Zhi-Qing Hua,*, Wei-Hua Zhaoa, Yukihiko Harab and Tadakatsu Shimamuraa

a Department of Microbiology and Immunology, Showa University School of Medicine; b Tokyo Food Techno Co., Ltd, Tokyo, Japan

Compared with ampicillin, oxacillin, cefmetazole and imipenem, the combination of ampicillin and sulbactam at a constant ratio of 2:1 showed the greatest effect against 28 clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA), but MICs of ampicillin/sulbactam were still above the resistance breakpoint. When ampicillin/sulbactam was further combined with epigallocatechin gallate (EGCg, a main constituent of tea catechins), the MIC90 of ampicillin/ sulbactam was reduced to 4 mg/L, the susceptibility breakpoint. The fractional inhibitory concentration indices were between 0.19 and 0.56 in combination with 6.25 and 25 mg/L EGCg, respectively, indicating that ampicillin/sulbactam and EGCg combination may be effective against MRSA infections.

* Corresponding author. Tel: +81-3-3784-8131; Fax: +81-3-3784-3069; E-mail: zqhu{at}med.showa-u.ac.jp


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