Journal of Antimicrobial Chemotherapy (2001) 48, 295-297
© 2001 The British Society for Antimicrobial Chemotherapy
Brief report |
A 9 year study of clarithromycin and metronidazole resistance in Helicobacter pylori from Spanish children
a Department of Microbiology, Hospital Universitario de la Princesa, Diego de León 62, 28006 Madrid; b Gastroenterology Unit, Hospital del Niño Jesus, Madrid, Spain
The evolution of clarithromycin, metronidazole and amoxycillin resistance in 246 Spanish Helicobacter pylori clinical isolates, obtained from paediatric patients during a 9 year period, was determined by an agar dilution technique. Clarithromycin resistance (MIC 1 mg/L) was 2.27% (IC95 0.05–12.02) in 1991–1993, 20.98% (IC95 12.72–31.46) in 1994–1996 and 28.33% (IC95 20.48–37.28) in 1997–1999 (P < 0.01). Metronidazole resistance (MIC 8 mg/L) was 7.14% (IC95 1.49–19.48) in 1991–1993, 20.25% (IC95 12.04–30.79) in 1994–1996 and 43.90% (IC95 32.95–55.30) in 1997–1999 (P < 0.01). Amoxycillin resistance was not found (all strains showed MICs < 2 mg/L).
* Corresponding author. Tel/Fax: +34-913-090047; E-mail: mlbrea{at}microb.net
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