Journal of Antimicrobial Chemotherapy (2001) 48, 291-294
© 2001 The British Society for Antimicrobial Chemotherapy
Brief report |
Genetic and phenotypic characterization of macrolide resistance in group A streptococci isolated from adults with pharyngo-tonsillitis in France
a Laboratoire de Biologie Médicale BIO VSM, 10 rue de la Gare, F-77360 Vaires-sur-Marne; b Laboratoires Abbott, Rungis; c Service de Microbiologie, Centre Hospitalo-Universitaire Robert Debré, Paris; d Service des Maladies Infectieuses, Centre Hospitalo-Universitaire du Bocage, Dijon, France
Three hundred and three strains of group A streptococci (GAS) isolated from adults with pharyngitis were tested to evaluate their phenotype of resistance to macrolides–lincosamides and to search for macrolide resistance genes. MICs of clarithromycin were determined. The overall rate of resistance to both erythromycin and clarithromycin was 9.6%. Constitutive, inducible and M phenotypes of resistance were detected in 4.3, 2 and 3.3% of strains, respectively. All constitutive phenotypes harboured ermB genes, whereas inducible phenotypes had the ermTR gene and M phenotypes had the mefA gene. In France, the current resistance rate of GAS to erythromycin and clarithromycin remains low.
Corresponding author. Tel: +33-1-64-72-47-57; Fax: +33-1-64-72-47-58; E-mail: pweber.biovsm{at}wanadoo.fr
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