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Journal of Antimicrobial Chemotherapy (2001) 48, 275-278
© 2001 The British Society for Antimicrobial Chemotherapy

Brief report

Erythromycin inhibits Pseudomonas aeruginosa-induced tumour necrosis factor-{alpha} production in human whole blood

Marc J. Schultza,b,*, Peter Speelmanc and Tom van der Polla,c

a Laboratory of Experimental Internal Medicine, b Department of Intensive Care Medicine and c Department of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, The Netherlands

Erythromycin has been shown to be beneficial for panbronchiolitis, a disorder linked to infection with Pseudomonas aeruginosa. Erythromycin, but not the anti-Pseudomonas antibiotics imipenem, ceftazidime, gentamicin and ciprofloxacin, caused a dose-dependent decrease in the production of tumour necrosis factor (TNF)-{alpha} by whole blood stimulated with heat-killed P. aeruginosa. The release of interleukin (IL)-10, IL-6, interferon-{gamma} and IL-8 was inhibited only at the highest erythromycin concentration. Inhibition of TNF-{alpha} production by erythromycin may, at least in part, explain the efficacy of this macrolide during panbronchiolitis despite its lack of activity for P. aeruginosa.

* Correspondence address. Department of Intensive Care Medicine, C3-326, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. Tel: +31-20-5669111; Fax: +31-20-6972988; E-mail: m.j.schultz{at}amc.uva.nl


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M. J. Schultz
Macrolide activities beyond their antimicrobial effects: macrolides in diffuse panbronchiolitis and cystic fibrosis
J. Antimicrob. Chemother., July 1, 2004; 54(1): 21 - 28.
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