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Journal of Antimicrobial Chemotherapy (2001) 48, 83-87
© 2001 The British Society for Antimicrobial Chemotherapy

In vitro comparison of the antimycotic activity of a miconazole–HP-ß-cyclodextrin solution with a miconazole surfactant solution

Géraldine Piela,*, Marie Pierre Hayetteb, Ermanno Pavonia, Brigitte Evrarda, Thierry Van Heesa, Sandrine Henri de Hassonvillea, Patrick De Molb and Luc Delattrea

a Laboratoires de Technologie Pharmaceutique and b Laboratoire de Microbiologie Médicale, Institut de Pharmacie, Université de Liège, Belgium

The antimycotic activity of a new parenteral solution containing miconazole was compared with that of a marketed solution (Daktarin IV solution). This solution has been withdrawn from the Belgian market, probably because of toxic effects related to the presence of polyoxyl 35 castor oil. We propose a new formulation containing miconazole (10 mg/mL) (like the marketed solution), in combination with hydroxypropyl-ß-cyclodextrin and lactic acid. The MICs of these two solutions were determined by a broth microdilution method (based on NCCLS guidelines) for 67 yeasts and 50 filamentous fungi isolates. This study shows that the MICs obtained with these two solutions are not significantly different.

* *Corresponding author. Tel: +32-4-366-43-07; Fax: +32-4-366-43-02; E-mail: Geraldine.Piel{at}ulg.ac.be


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