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Journal of Antimicrobial Chemotherapy (2001) 48, 137-140
© 2001 The British Society for Antimicrobial Chemotherapy

Brief report

The in vivo activity of olamufloxacin (HSR-903) in systemic and urinary tract infections in mice

Satoshi Yoshizumia,*, Yoshie Takahashib, Mitsuo Muratab, Haruki Domona, Nobuhiko Furuyaa, Yoshikazu Ishiia, Tetsuya Matsumotoa, Akira Ohnoa, Kazuhiro Tatedaa, Shuichi Miyazakia and Keizo Yamaguchia

a Department of Microbiology, Toho University School of Medicine, Tokyo; b Research Department, Research & Development Division, Hokuriku Seiyaku Co., Ltd, Fukui, Japan

The in vivo activity of olamufloxacin (HSR-903), a new fluoroquinolone, was evaluated and compared with ciprofloxacin, sparfloxacin and levofloxacin. Olamufloxacin was active against systemic infection in mice inoculated with both Gram-positive and -negative bacteria. Olamufloxacin had equal efficacy for experimental urinary tract infections in mice caused by Pseudomonas aeruginosa.

* Correspondence address. Research Department, Hokuriku Seiyaku Co., Ltd, 1-1 Inokuchi 37, Katsuyama, Fukui 911-8555, Japan. Tel: +81-779-88-5121; Fax: +81-779-88-3021; E-mail: satoshi.yoshizumi{at}hokuriku-seiyaku.co.jp


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