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Journal of Antimicrobial Chemotherapy (2001) 48, 109-111
© 2001 The British Society for Antimicrobial Chemotherapy

Brief report

The effect of amiloride on amphotericin B-induced hypokalaemia

David T. Beardena,* and Lance A. Munceyb

a Department of Pharmacy Practice, Albany College of Pharmacy, 106 New Scotland Avenue, Albany, NY 12208; b University of Utah Hospitals and Clinics, Salt Lake City, UT 84132, USA

Amiloride was administered to 19 oncology patients exhibiting marked amphotericin B-induced electrolyte wasting. Mean serum potassium concentrations increased in the 5 days preceding and following administration (3.4 ± 0.5 versus 3.9 ± 0.8 mmol/L, P = 0.002). A trend towards decreased potassium supplementation was also observed (48.0 ± 66.5 versus 29.4 ± 43.2 mmol/day, P = 0.12). Amiloride is a therapeutic option to decrease potassium wasting in patients being treated with amphotericin B.

* Corresponding author. Tel: +1-518-445-7334; Fax: +1-518-445-7302; E-mail: beardend{at}acp.edu


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