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Journal of Antimicrobial Chemotherapy (2001) 48, 105-107
© 2001 The British Society for Antimicrobial Chemotherapy

Brief report

In vitro effects of photodynamic therapy on Aspergillus fumigatus

Joseph S. Friedberga,*, Cynthia Skemaa, Eric D. Bauma, Jeffrey Burdicka, Sergei A. Vinogradovb, David F. Wilsonb, Annamarie D. Horanc and Irving Nachamkind

a Departments of Surgery, b Biochemistry and Biophysics, c Radiation Oncology and d Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

Photodynamic therapy is a technique for killing cells with visible light after pretreatment with a photosensitizing agent. We demonstrated significant in vitro fungicidal activity against Aspergillus fumigatus of the photosensitizer Green 2W, activated with 630 nm light. This effect was both inoculum- and light dose-dependent. At a Green 2W concentration of 31.5 mg/L, there was complete killing of 2.7 x 101 cfu/mL with a light dose of 110 J/cm2 and up to 2.7 x 106 cfu/mL with a light dose of 385 J/cm2.

* Correspondence address. Department of Surgery, Thomas Jefferson University, 1025 Walnut Street, 605 College Building, Philadelphia, PA 19107, USA. Tel: +1-215-955-2996; Fax: +1-215-923-1420; E-mail: joseph.friedberg{at}mail.TJU.edu


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