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Journal of Antimicrobial Chemotherapy (2001) 47, 871-874
© 2001 The British Society for Antimicrobial Chemotherapy

Brief report

Enhanced fungicidal activity of N-chlorotaurine in nasal secretion

Markus Nagla,*, Cornelia Lass-Flörla, Andreas Neherb, Andreas Gunkelb and Waldemar Gottardia

a Institute of Hygiene and Social Medicine, Leopold-Franzens-University of Innsbruck, Fritz-Pregl-Strasse 3, A-6010 Innsbruck; b Department of Otorhinolaryngology, University Hospital of Innsbruck, Innsbruck, Austria

The antifungal activity of N-chlorotaurine (NCT), a long-lived oxidant produced by stimulated human leucocytes, was investigated. Incubation of Aspergillus spp., Candida spp., Fusarium spp., Penicillium spp. and Alternaria spp. in 1% NCT (55 mM) for 1–4 h produced a log10 reduction in cfu of between 1 and 4. In samples of nasal secretion, killing was significantly hastened (30 min), which may be explained by the formation of monochloramine by halogenation of ammonium, which was found at a concentration of 1 mM in these samples. For these reasons, NCT is of interest as a new agent for treatment of local inflammatory mycosis, e.g. eosinophilic fungal rhinosinusitis.

* Corresponding author. Tel: +43-512-507-3430; Fax:+43-512-507-2870; E-mail: m.nagl{at}uibk.ac.at


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