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Journal of Antimicrobial Chemotherapy (2001) 47, 863-866
© 2001 The British Society for Antimicrobial Chemotherapy

Distribution of resistance genes tet(M), aph3'-III, catpC194 and the integrase gene of Tn1545 in clinical Streptococcus pneumoniae harbouring erm(B) and mef(A) genes in Spain

Cristina Seral,*, F. Javier Castillo, M. Carmen Rubio-Calvo, Asunción Fenoll, Concepción García and Rafael Gómez-Lus

Department of Microbiology, University Hospital ‘Lozano Blesa’, San Juan Bosco 15, 50009 Zaragoza, Spain

The most prevalent macrolide resistance phenotype and genotype among pneumococcal isolates was the cMLSB phenotype [erm(B) or erm(B)/mef(A)] (91.3%). We studied the distribution of other resistance genes, tet(M), catpC194, aph3'-III, in these strains, seeing evolution at work in that some strains carried different combinations of resistance determinants. The most prevalent patterns associated with resistance to erythromycin [erm(B)] were resistance to tetracycline [tet(M)] and chloramphenicol (catpC194) (48.2%) or resistance to tetracycline [tet(M)] alone (42.2%). In our isolates of Streptococcus pneumoniae there was a strong association of the erm(B) and tet(M) genes with Tn1545-related elements.

* Corresponding author. Tel: +34-976-556400; E-mail: c.seral.000{at}recol.es


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